Valproic acid: a relevant thromboprophylactic strategy?
نویسندگان
چکیده
منابع مشابه
VALPROIC ACID- valproic acid solution Par Pharmaceutical ----------
WARNINGS: LIFE THREATENING ADVERSE REACTIONS See full prescribing information for complete boxed warning. Hepato toxicity, including fatalities, usually during first 6 months o f treatment. Children under the age of two years and patients with mitochondrial disorders are at higher risk. Monitor patients c losely, and perform serum liver testing prior to therapy and at frequent intervals thereaf...
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We present two case reports of drug interaction between valproic acid and meropenem. In comparison with expected population-kinetic based serum levels, we observed 90.8 and 93.5% decrease in valproic acid serum levels during concomitant administration with meropenem. If carbapenems need to be administered to valproic acid treated patient, other anticonvulsant addition seems to be the appropriat...
متن کاملIs Valproic Acid Ototoxic?
7 A forum for case studies, clinical notes and observations, and other clinical material that does not have a traditional research format. V alproic acid (VPA), or valproate, was first discovered in 1882 by Burton, but its anticonvulsant properties were not Although thousands of patients have been treated with VPA, only recently has the question of VPA ototoxicity been raised. The first reports...
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During the course of a prospective serial study over a period of one year, findings compatible with immune-mediated thrombocytolysis accompanied the administration of valproic acid in about half of 45 children with epilepsy. Thrombocytopenia occurred in 15 and neutropenia in 12 patients, but was transient and self-limiting in each. The association is probably one of cause and effect, and it may...
متن کاملValproic acid producing a Reye-like syndrome.
.Although several cases of acute hepatic failure associated with the administration of valproic acid (VPA) have been reported, the pathogenesis of this problem remains unclear. We report the case of a 40 month old male with a chronic seizure disorder treated with VPA and phenytoin for two years, who developed sudden progressive neurological deterioration with evidence of increased intracranial ...
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ژورنال
عنوان ژورنال: Journal of Thrombosis and Haemostasis
سال: 2016
ISSN: 1538-7933
DOI: 10.1111/jth.13528